A study of role of amikacin in peritonitis model of rat

Introduction: Intra-peritoneal infection is responsible for significant mortality in number of cases. Even after well-known side effects aminoglycosides are considered for prophylaxis and treatment of peritonitis. It is essential to start antibiotics as soon as infection sets in. The advantages of using amikacin are; it is broad spectrum, has increased efficacy when used singly or in combination, bactericidal and prevents emergence of resistance. The work was planned to study the role of amikacin on bacterial growth in an experimental model of peritonitis. Materials and method: This study was done on 44 healthy Mus Norvagicus Albinus rats to see the effect of Amikacin in cases of peritonitis on bacterial count in peritoneal fluid. The rats were divided in two groups. Peritonitis was induced by instilling suspension of E.coli inside the peritoneal cavity of rats and studied for its growth. Results: There was lesser growth of bacteria in the group in which amikacin was used. The t value tX/Y = 5.59; p˂0.05 and the p value is significant. It shows that amikacin plays a greater role in inhibiting bacterial growth and reducing bacterial counts in peritonitis. Discussion: Antibiotics play an important role in preventing infections, when there are chances of infection due to peritonitis. There is also reduction in rates of bacterial resistance when antibiotics are given in combination of amikacin. Even in pediatric age group a single daily dose of amikacin produces same results when compared to multiple doses of amikacin, the safety of drug also increases by low dosage of drug Conclusion: amikacin plays a greater role in inhibiting bacterial growth and reducing bacterial counts in peritonitis.